2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Related Products

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103324
    Palmitoylisopropylamide
    		Inhibitor
    Palmitoylisopropylamide is a Palmitoylethanolamide analogue inhibits [3H]-Anandamide metabolism with a pI50 of 4.89.
    Palmitoylisopropylamide
  • HY-168361
    8β-Hydroxy-exo-THC
    8β-Hydroxy-exo-THC is a cannabinoid ether analogue with a weaker affinity for receptor sites, with an IC50 of 1.2 μM.
    8β-Hydroxy-exo-THC
  • HY-121011
    Cannabigerorcin
    Cannabigerorcin is a phenolic compound found in cannabis plants, featuring a diphenol backbone and a terpene side chain. By reacting with radiolabeled methylmagnesium carbonate (MMC), its carboxyl group can be 14C-labeled. Radiolabeled Cannabigerorcin is widely used in research on cannabinoid biosynthesis pathways and metabolic processes.
    Cannabigerorcin
  • HY-168418
    ADB-BINACA
    ADB-BINACA is categorized as a synthetic cannabinoid.
    ADB-BINACA
  • HY-170699
    Δ8-THCBA-A
    Δ8-THCBA-A (Δ8-Tetrahydrocannabibutolic acid A) is structurally similar to known phytocannabinoids.
    Δ8-THCBA-A
  • HY-134055
    Arachidonoyl-N,N-dimethyl amide
    Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
    Arachidonoyl-N,N-dimethyl amide
  • HY-W715183
    6α-Oxycodol N-oxide
    6α-Oxycodol N-oxide is structurally categorized as an opioid. 6α-Oxycodol N-oxide is a metabolite of Oxycodone.
    6α-Oxycodol N-oxide
  • HY-103336
    Tocrifluor 1117
    		Antagonist
    Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251 (HY-15443), is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm).
    Tocrifluor 1117
  • HY-14791AR
    (±)-Ibipinabant (Standard)
    		Antagonist
    (±)-Ibipinabant (Standard) is the analytical standard of (±)-Ibipinabant. This product is intended for research and analytical applications. (±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.
    (±)-Ibipinabant (Standard)
  • HY-170664
    Hexocannabitriol
    Hexocannabitriol is structurally similar to known phytocannabinoids.
    Hexocannabitriol
  • HY-172080
    (-)-7-Nor-7-carboxy cannabidiol
    (-)-7-Nor-7-carboxy cannabidiol is a phytocannabinoid metabolite. (-)-7-Nor-7-carboxy cannabidiol is a metabolite of Cannabidiol.
    (-)-7-Nor-7-carboxy cannabidiol
  • HY-134038
    Cannabinol methyl ether
    Cannabinol methyl ether is a phytocannabinoid.
    Cannabinol methyl ether
  • HY-116661
    Cannabigerovarin
    Cannabigerovarin (CRM) (Item No. 29117) is a certified reference material categorized as a phytocannabinoid.1 This product is intended for research and forensic applications.
    Cannabigerovarin
  • HY-129821
    PTI-1
    PTI-1 is a synthetic cannabinoid (CB) that contains the 1-pentyl-indole structure.
    PTI-1
  • HY-170476
    Δ8-THCB
    		Ligand
    Δ8-THCB (∆8-Tetrahydrocannabutol) is a structural analog of phytocannabinoids. Δ8-THCB is also an analog of Δ8-tetrahydrocannabinol.
    Δ8-THCB
  • HY-137543
    Δ8-Tetrahydrocannabivarin
    Δ8-Tetrahydrocannabivarin is a cannabinoid.
    Δ8-Tetrahydrocannabivarin
  • HY-170047A
    11-Nor-9(S)-carboxy-hexahydrocannabinol
    11-Nor-9(S)-carboxy-hexahydrocannabinol (11-Nor-9α-carboxy-HHC) is structurally similar to known phytocannabinoids.
    11-Nor-9(S)-carboxy-hexahydrocannabinol
  • HY-15443R
    AM251 (Standard)
    		Antagonist
    AM251 (Standard) is the analytical standard of AM251. This product is intended for research and analytical applications. AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC50 of 39 nM.
    AM251 (Standard)
  • HY-165082
    Tricosanoyl ethanolamide
    		Activator
    Tricosanoyl ethanolamide is a member of endocannabinoids and its structure consists of ethanolamine and tricosanoic acid, which contains 23 carbon atoms. Tricosanoyl ethanolamide can be used for research of diseases related to the endocannabinoid system.
    Tricosanoyl ethanolamide
  • HY-170727
    Cannabinol acetate
    Cannabinol acetate (Acetylcannabinol) is structurally similar to known phytocannabinoids.
    Cannabinol acetate
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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